1953133-47-5

1953133-47-5 structure

Name: Giredestrant
Chemical Name: Giredestrant
CAS Number: 1953133-47-5
Molecular Formula: C₂₇H₃₁F₅N₄O
Molecular Weight: 522.55
Catalog: Signaling Pathways Others Estrogen Receptor/ERR
Create Date: 2020-06-01 11:31:16
Modify Date: 2024-01-02 22:59:33
Giredestrant (GDC-9545), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity[1].

Name	Giredestrant
Synonyms	GDC-9545

Description	Giredestrant (GDC-9545), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
Target	ER
In Vitro	Giredestrant (GDC-9545) is a novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes. The highly potent in vivo efficacy of Giredestrant likely arises due to the particular combination of high binding potency, full suppression of ER signaling, and an improved DMPK profile[1].
References	[1]. C Metcalfe, et al. Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes