Shanghai Nianxing Industrial Co., Ltd
China
Product Name: HL271
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

1422365-52-3

1422365-52-3 structure

1422365-52-3 structure

Name: HL271
Chemical Name: HL271
CAS Number: 1422365-52-3
Molecular Formula: C₁₃H₁₇ClF₃N₅O
Molecular Weight: 351.76
Catalog: Signaling Pathways Epigenetics AMPK
Create Date: 2020-06-01 08:05:06
Modify Date: 2024-01-11 12:05:32
HL271, a chemical derivative of metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment[1][2].

Name	HL271

Description	HL271, a chemical derivative of metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> AMPK Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Research Areas >> Neurological Disease
Target	AMPK[1][2]
In Vitro	HL271 (0.31-10 μM) phosphorylates AMPKα1 Thr172 in a dose- and time-dependent manner in NIH3T3 mouse fibroblast cells[1]. HL271 does not affect the expression of key factors involved in glucose homeostasis such as glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1)[1]. Western Blot Analysis[1] Cell Line: NIH3T3 cells Concentration: 0.31 μM, 0.62 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM Incubation Time: 4 hours Result: Significantly increased the AMPK phosphorylation rate.
In Vivo	HL271 does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity[1]. HL271 (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety[2]. HL271 significantly attenuates the aging-induced decline in novel object recognition memory and spatial working memory[2]. HL271 significantly increases AMPK activation in the hippocampus of aged mice[2]. Animal Model: C57BL/6J mice (young group/12~16 weeks, old groups/20~22 months)[2] Dosage: 50 mg/kg Administration: Oral administration (in drinking water), for 2 months Result: Attenuated age-related cognitive decline.
References	[1]. Row H, et al. HL271, a novel chemical compound derived from metformin, differs from metformin in its effects on the circadian clock and metabolism. Biochem Biophys Res Commun. 2016 Jan 15;469(3):783-9. [2]. Bang E, et al. The Improving Effect of HL271, a Chemical Derivative of Metformin, a Popular Drug for Type II Diabetes Mellitus, on Aging-induced Cognitive Decline. Exp Neurobiol. 2018 Feb;27(1):45-56.

Molecular Formula	C₁₃H₁₇ClF₃N₅O
Molecular Weight	351.76

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.