1254044-38-6

1254044-38-6 structure

Name: (11-((4-Hydroxy-3-methoxybenzoyl)oxy)undecyl)triphenylphosphonium bromide
Chemical Name: Mito-apocynin (C11)
CAS Number: 1254044-38-6
Molecular Formula: C₃₇H₄₄BrO₄P
Molecular Weight: 663.62
Catalog: Research Areas Neurological Disease
Create Date: 2020-06-01 20:53:05
Modify Date: 2024-01-21 13:26:11
Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP+ cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function[1].

Name	Mito-apocynin (C11)

Description	Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP+ cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function[1].
Related Catalog	Research Areas >> Neurological Disease
In Vivo	Mito-apocynin-C11 (3 mg/kg; oral gavage; 3x/wk from 3 months of age until 15 months) markedly improves the coordinated motor function and olfactory function in LRRK2R1441G mice[1]. Animal Model: LRRK2R1441G mice[1] Dosage: 3 mg/kg Administration: Oral gavage; 3x/wk from 3 months of age until 15 months Result: Markedly improved the coordinated motor function and olfactory function.
References	[1]. Dranka BP, et al. A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease. Neurosci Lett. 2014 Nov 7;583:159-64.

Molecular Formula	C₃₇H₄₄BrO₄P
Molecular Weight	663.62

Hazard Codes	Xn