934014-05-8

934014-05-8 structure

934014-05-8 structure

Name: MRS2698
Chemical Name: MRS2698
CAS Number: 934014-05-8
Molecular Formula: C₉H₁₆N₃O₁₃P₃S
Molecular Weight: 499.22
Catalog: Signaling Pathways GPCR/G Protein P2Y Receptor
Create Date: 2020-06-01 11:14:00
Modify Date: 2024-01-29 10:33:54
MRS2698 is a potent and highly selective P2Y2 receptor agonist with an EC50 of 8 nM. MRS2698 is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 receptors[1][2].

Name	MRS2698

Description	MRS2698 is a potent and highly selective P2Y2 receptor agonist with an EC50 of 8 nM. MRS2698 is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 receptors[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> P2Y Receptor Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	EC50: 8 nM (P2Y2 receptor), 2400 nM (P2Y4 receptor)[1]
In Vitro	MRS2698 is the 2′-amino-2-thio derivative of UTP and is one of the most potent and selective P2Y2R agonist. MRS2698 is 6-fold more potent than the endogenous agonist UTP[1][2].
References	[1]. Ivanov AA, et al. Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. J Med Chem. 2007 Mar 22;50(6):1166-76. [2]. Rafehi M, et al. Tools and drugs for uracil nucleotide-activated P2Y receptors. Pharmacol Ther. 2018 Oct;190:24-80.

Molecular Formula	C₉H₁₆N₃O₁₃P₃S
Molecular Weight	499.22