1782532-06-2

1782532-06-2 structure

Name: PD 168568 dihydrochloride
Chemical Name: PD 168568 dihydrochloride
CAS Number: 1782532-06-2
Molecular Formula: C₂₂H₂₉Cl₂N₃O
Molecular Weight: 422.39
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2020-06-01 09:16:50
Modify Date: 2024-01-17 20:31:25
PD 168568 dihydrochloride is an orally active and selective D4 dopamine receptor antagonist, with a Ki of 8.8 nM[1].

Name	PD 168568 dihydrochloride

Description	PD 168568 dihydrochloride is an orally active and selective D4 dopamine receptor antagonist, with a Ki of 8.8 nM[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D4 Receptor:8.8 nM (Ki)
In Vitro	PD 168568 dihydrochloride has good selective for D4 receptor, with a Ki of 1842 nM for D2 receptor[1].
In Vivo	PD 168568 dihydrochloride has ability to inhibit amphetamine stimulated locomotor activity in the rat[1]. Animal Model: Rat[1] Dosage: 3 mg/kg Administration: Oral administration Result: Inhibit amphetamine (0.5 mg/kg, i.p.) stimulated locomotor activity.
References	[1]. Belliotti TR, et al. Isoindolinone enantiomers having affinity for the dopamine D4 receptor. Bioorg Med Chem Lett. 1998 Jun 16;8(12):1499-502.