1835705-74-2

1835705-74-2 structure

Name: Pomalidomide-PEG6-butyl iodide
Chemical Name: Pomalidomide-PEG6-butyl iodide
CAS Number: 1835705-74-2
Molecular Formula: C₃₁H₄₄IN₃O₁₁
Molecular Weight: 761.60
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2020-06-01 11:59:30
Modify Date: 2024-01-10 21:10:46
Pomalidomide-PEG6-butyl iodide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology[1].

Name	Pomalidomide-PEG6-butyl iodide

Description	Pomalidomide-PEG6-butyl iodide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.

Molecular Formula	C₃₁H₄₄IN₃O₁₁
Molecular Weight	761.60