Pomalidomide-PEG6-butyl iodide

Modify Date: 2024-01-10 21:10:46

Pomalidomide-PEG6-butyl iodide Structure
Pomalidomide-PEG6-butyl iodide structure
 Common Name Pomalidomide-PEG6-butyl iodide
CAS Number 1835705-74-2 Molecular Weight 761.60
Density N/A Boiling Point N/A
Molecular Formula C31H44IN3O11 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pomalidomide-PEG6-butyl iodide


Pomalidomide-PEG6-butyl iodide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology[1].

 Names

Name Pomalidomide-PEG6-butyl iodide

 Pomalidomide-PEG6-butyl iodide Biological Activity

Description Pomalidomide-PEG6-butyl iodide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology[1].
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.

 Chemical & Physical Properties

Molecular Formula C31H44IN3O11
Molecular Weight 761.60
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