Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Py-MPB-amino-C3-PBD
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Purity: 98.0%
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2412924-07-1

2412924-07-1 structure

2412924-07-1 structure

Name: Py-MPB-amino-C3-PBD
Chemical Name: Py-MPB-amino-C3-PBD
CAS Number: 2412924-07-1
Molecular Formula: C₄₁H₄₄N₈O₆
Molecular Weight: 744.84
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2020-06-01 11:32:58
Modify Date: 2025-08-21 21:15:48
Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1].

Name	Py-MPB-amino-C3-PBD

Description	Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Signaling Pathways >> Anti-infection >> Bacterial
Target	Pyrrolobenzodiazepines
In Vitro	Py-MPB-amino-C3-PBD (compound 73) shows cytotoxicity with IC50s of 301, 144.1 and 37.5 nM for U138-MG, A431, and REH cells, respectively. Py-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12, with potency of 2 pg/mL determined[1].
References	[1]. David Edwin Thurston, et al. Polycyclic amides as cytotoxic agents. WO2020049286A1.

Molecular Formula	C₄₁H₄₄N₈O₆
Molecular Weight	744.84

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