Py-MPB-amino-C3-PBD

Modify Date: 2025-08-21 21:15:48

Py-MPB-amino-C3-PBD structure	Common Name	Py-MPB-amino-C3-PBD
	CAS Number	2412924-07-1	Molecular Weight	744.84
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₁H₄₄N₈O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Py-MPB-amino-C3-PBD

Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1].

Name	Py-MPB-amino-C3-PBD

Description	Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Signaling Pathways >> Anti-infection >> Bacterial
Target	Pyrrolobenzodiazepines
In Vitro	Py-MPB-amino-C3-PBD (compound 73) shows cytotoxicity with IC50s of 301, 144.1 and 37.5 nM for U138-MG, A431, and REH cells, respectively. Py-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12, with potency of 2 pg/mL determined[1].
References	[1]. David Edwin Thurston, et al. Polycyclic amides as cytotoxic agents. WO2020049286A1.

Molecular Formula	C₄₁H₄₄N₈O₆
Molecular Weight	744.84
InChIKey	KZQHDCMQELKFIS-HKBQPEDESA-N
SMILES	COc1cc2c(cc1OCCCC(=O)Nc1cc(C(=O)Nc3ccc(-c4cc(C(=O)Nc5ccncc5)n(C)c4)cc3)n(C)c1)NCC1CCCCN1C2=O

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Py-MPB-amino-C3-PBD
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

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