1781880-34-9

1781880-34-9 structure

Name: RP 001 hydrochloride
Chemical Name: RP-001 hydrochloride
CAS Number: 1781880-34-9
Molecular Formula: C₂₄H₂₅ClN₄O₄
Molecular Weight: 468.93
Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
Create Date: 2020-06-01 16:57:26
Modify Date: 2024-01-15 13:57:16
RP-001 hydrochloride is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 hydrochloride induces internalization and polyubiquitination of S1P1. RP-001 hydrochloride has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1].

Name	RP-001 hydrochloride

Description	RP-001 hydrochloride is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 hydrochloride induces internalization and polyubiquitination of S1P1. RP-001 hydrochloride has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Neurological Disease
In Vitro	RP-001 hydrochloride elicits dose-dependent lymphopenia of CD4+ T cells. RP-001 hydrochloride induces acute lymphopenia with rapid recovery to untreated levels[1].
In Vivo	RP-001 hydrochloride causes dose-dependent rapid lymphopenia with an EC50 of 0.03 mg/kg[1].
References	[1]. Cahalan SM, et al. Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice. Nat Chem Biol. 2011 May;7(5):254-6.

Molecular Formula	C₂₄H₂₅ClN₄O₄
Molecular Weight	468.93