2204226-02-6

2204226-02-6 structure

Name: Thalidomide-O-amido-PEG-C2-NH2 hydrochloride
Chemical Name: Thalidomide-O-amido-PEG-C2-NH2 hydrochloride
CAS Number: 2204226-02-6
Molecular Formula: C₁₉H₂₃ClN₄O₇
Molecular Weight: 454.86
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2020-06-01 12:36:37
Modify Date: 2025-09-10 20:05:01
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

Name	Thalidomide-O-amido-PEG-C2-NH2 hydrochloride
Synonyms	MFCD32063469

Description	Thalidomide-O-amido-PEG-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Chessum NEA, et al. Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766). J Med Chem. 2018 Feb 8;61(3):918-933.

Molecular Formula	C₁₉H₂₃ClN₄O₇
Molecular Weight	454.86

Hazard Codes	Xi