2211174-73-9

2211174-73-9 structure

Name: Carboxy-PEG12-C2-Thiol
Chemical Name: Thiol-PEG12-acid
CAS Number: 2211174-73-9
Molecular Formula: C₂₇H₅₄O₁₄S
Molecular Weight: 634.77
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-06-01 21:24:04
Modify Date: 2024-01-09 16:21:05
Thiol-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Thiol-PEG12-acid

Description	Thiol-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562