Carboxy-PEG12-C2-Thiol

Modify Date: 2024-01-09 16:21:05

Carboxy-PEG12-C2-Thiol Structure
Carboxy-PEG12-C2-Thiol structure
Common Name Carboxy-PEG12-C2-Thiol
CAS Number 2211174-73-9 Molecular Weight 634.77
Density N/A Boiling Point N/A
Molecular Formula C27H54O14S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Carboxy-PEG12-C2-Thiol


Thiol-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Thiol-PEG12-acid

 Carboxy-PEG12-C2-Thiol Biological Activity

Description Thiol-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C27H54O14S
Molecular Weight 634.77
Storage condition -20°C
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