Shanghai Nianxing Industrial Co., Ltd
China
Product Name: AP C5
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: AP C5
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

2234272-10-5

2234272-10-5 structure

2234272-10-5 structure

Name: AP C5
Chemical Name: AP-C5
CAS Number: 2234272-10-5
Molecular Formula: C₁₆H₁₃N₅
Molecular Weight: 275.31
Catalog: Research Areas Metabolic Disease
Create Date: 2020-08-11 15:26:09
Modify Date: 2024-08-04 16:20:29
AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, which can be used for the research of diarrheal disease[1].

Name	AP-C5

Description	AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, which can be used for the research of diarrheal disease[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	pIC50: 7.2 (cGKII)[1]
In Vitro	AP-C5 shows potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation and effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue[1]. AP-C5 potentiates cAMP signaling by PDE inhibition[1]. AP-C5 (20 μM) partially blocks the heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum[1].
References	[1]. Marcel J C Bijvelds, et al. Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J Biol Chem. 2018 May 25;293(21):8173-8181.

Molecular Formula	C₁₆H₁₃N₅
Molecular Weight	275.31