2234272-10-5
2234272-10-5 structure
- Name: AP C5
- Chemical Name: AP-C5
- CAS Number: 2234272-10-5
- Molecular Formula: C16H13N5
- Molecular Weight: 275.31
- Catalog: Research Areas Metabolic Disease
- Create Date: 2020-08-11 15:26:09
- Modify Date: 2024-08-04 16:20:29
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AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, which can be used for the research of diarrheal disease[1].
| Name | AP-C5 |
|---|
| Description | AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, which can be used for the research of diarrheal disease[1]. |
|---|---|
| Related Catalog | |
| Target |
pIC50: 7.2 (cGKII)[1] |
| In Vitro | AP-C5 shows potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation and effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue[1]. AP-C5 potentiates cAMP signaling by PDE inhibition[1]. AP-C5 (20 μM) partially blocks the heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum[1]. |
| References |
| Molecular Formula | C16H13N5 |
|---|---|
| Molecular Weight | 275.31 |