713544-47-9

713544-47-9 structure

Name: APETx2 TFA
Chemical Name: APETx2
CAS Number: 713544-47-9
Molecular Formula: C₁₉₆H₂₈₀N₅₄O₆₁S₆
Molecular Weight: 4561.00
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2020-08-11 14:15:21
Modify Date: 2024-01-22 18:56:50
APETx2, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC50 of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain[1][2].

Name	APETx2

Description	APETx2, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC50 of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vitro	APETx2 (i.t. or i.m. application, 0.022 to 2.2 µM) resulted in a potent and complete reversal of established mechanical hypersensitivity in the complete Freund's adjuvant (CFA) inflammatory pain model[2].
References	[1]. Sylvie Diochot, et al. A New Sea Anemone Peptide, APETx2, Inhibits ASIC3, a Major Acid-Sensitive Channel in Sensory Neurons. EMBO J. 2004 Apr 7;23(7):1516-25. [2]. Jerzy Karczewski, et al. Reversal of Acid-Induced and Inflammatory Pain by the Selective ASIC3 Inhibitor, APETx2. Br J Pharmacol. 2010 Oct;161(4):950-60.

Molecular Formula	C₁₉₆H₂₈₀N₅₄O₆₁S₆
Molecular Weight	4561.00