2099681-71-5

2099681-71-5 structure

Name: AT-121 hydrochloride
Chemical Name: AT-121 hydrochloride
CAS Number: 2099681-71-5
Molecular Formula: C₂₄H₃₉ClN₄O₃S
Molecular Weight: 499.11
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2020-08-11 11:25:58
Modify Date: 2025-08-27 20:41:23
AT-121 hydrochloride is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 hydrochloride is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects[1].

Name	AT-121 hydrochloride

Description	AT-121 hydrochloride is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 hydrochloride is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
In Vivo	AT-121 hydrochloride (0.003-0.03 mg/kg; s.c.) produces potent antinociceptive effect[1]. Animal Model: Adult male and female rhesus monkeys[1] Dosage: 0.003-0.03 mg/kg Administration: Subcutaneous Result: Produced antinociceptive effects against an acute noxious stimulus, 50 °C water, in a dose-dependent.
References	[1]. Ding H, et al. A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates. Sci Transl Med. 2018;10(456):eaar3483.

Molecular Formula	C₂₄H₃₉ClN₄O₃S
Molecular Weight	499.11