1801433-90-8
1801433-90-8 structure
- Name: Biliatresone
- Chemical Name: Biliatresone
- CAS Number: 1801433-90-8
- Molecular Formula: C18H16O6
- Molecular Weight: 328.32
- Catalog: Research Areas Metabolic Disease
- Create Date: 2020-08-11 09:27:00
- Modify Date: 2025-08-25 11:36:39
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Biliatresone is a natural toxin isolated from Dysphania glomulifera and D. littoralis. Biliatresone, a 1,2-diaryl-2-propenone class of isoflavonoid, produces extrahepatic biliary atresia in a zebrafish model[1].
| Name | Biliatresone |
|---|
| Description | Biliatresone is a natural toxin isolated from Dysphania glomulifera and D. littoralis. Biliatresone, a 1,2-diaryl-2-propenone class of isoflavonoid, produces extrahepatic biliary atresia in a zebrafish model[1]. |
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| Related Catalog | |
| In Vitro | Biliatresone has a reduction in primary cilia and a dose-dependent decrease in visible microtubules, suggesting that Biliatresone decreases microtubule stability in primary neonatal mouse extrahepatic cholangiocytes[1]. Biliatresone (2 µg/ml; for 24 hours) shows disruption of the spheroid lumen and abnormal cholangiocyte polarity in mouse cholangiocyte[1]. |
| In Vivo | Biliatresone exhibits toxicity at doses of 0.065-1.0 μg/mL with a marked reduction and the lethal dose of Biliatresone in a zebrafish assay is 1 μg/mL[1]. Larvae treated at 5 dpf with low doses of biliatresone [0.0625 µg/ml (0.2 µM) and 0.125 µg/ml (0.4 µM)] shows only subtle gallbladder defects, whereas larvae treated with higher doses has pronounced morphological defects of the gallbladder and extrahepatic ducts[1]. |
| References |
| Molecular Formula | C18H16O6 |
|---|---|
| Molecular Weight | 328.32 |