Top Suppliers:I want be here

  • DC Chemicals Limited
  • China
  • Product Name: MB-0223
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

2247732-89-2

2247732-89-2 structure
2247732-89-2 structure
  • Name: MB 0223
  • Chemical Name: MB-0223
  • CAS Number: 2247732-89-2
  • Molecular Formula: C26H27N5OS
  • Molecular Weight: 457.59
  • Catalog: Signaling Pathways Cytoskeleton Dynamin
  • Create Date: 2020-08-07 12:45:57
  • Modify Date: 2024-01-16 12:24:02
  • MB-0223 is a potent and selective dynamin-related GTPase Drp1 partial inhibitor (IC50=1.3 μM) over other dynamin family members, Opa 1 and dynamin-1 (IC50>100 μM)[1].

Name MB-0223
Description MB-0223 is a potent and selective dynamin-related GTPase Drp1 partial inhibitor (IC50=1.3 μM) over other dynamin family members, Opa 1 and dynamin-1 (IC50>100 μM)[1].
Related Catalog
Target

IC50: 1.3 μM (Drp1)[1]

In Vitro MB-0223 (30 μM; 48 hours) increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion[1]. MB-0223 (0-100 μM) is a partial inhibitor and exhibits a maximum inhibition of 67% of Drp1 activity. MB-0223 exhibits >100-fold selectivity for Drp1 over two other dynamin-like GTPases, Opa1 and Dnm1[1].
References

[1]. Ashley Mallat,et al. Characterization of Small Molecule Inhibitors of Drp1.

Molecular Formula C26H27N5OS
Molecular Weight 457.59