1432728-49-8
1432728-49-8 structure
- Name: mGluR2 antagonist 1
- Chemical Name: mGluR2 antagonist 1
- CAS Number: 1432728-49-8
- Molecular Formula: C21H16FN3O3
- Molecular Weight: 377.37
- Catalog: Signaling Pathways GPCR/G Protein mGluR
- Create Date: 2020-08-08 04:47:43
- Modify Date: 2024-01-21 16:04:14
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mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability[1].
| Name | mGluR2 antagonist 1 |
|---|
| Description | mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability[1]. |
|---|---|
| Related Catalog | |
| Target |
mGluR2:9 nM (IC50) |
| In Vivo | In vivo, mGluR2 antagonist 1 (Compound 25) reverses the effect of mGluR2 agonist LY379268 in amphetamine-induced hyperlocomotion and shows good efficacy in the mouse delayed non-match to position assay at 10 mg/kg. |
| References |
| Molecular Formula | C21H16FN3O3 |
|---|---|
| Molecular Weight | 377.37 |