Shanghai Nianxing Industrial Co., Ltd
China
Product Name: mGluR2 antagonist 1
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: mGluR2 antagonist 1
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1432728-49-8

1432728-49-8 structure

1432728-49-8 structure

Name: mGluR2 antagonist 1
Chemical Name: mGluR2 antagonist 1
CAS Number: 1432728-49-8
Molecular Formula: C₂₁H₁₆FN₃O₃
Molecular Weight: 377.37
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2020-08-08 04:47:43
Modify Date: 2024-01-21 16:04:14
mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability[1].

Name	mGluR2 antagonist 1

Description	mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR2:9 nM (IC50)
In Vivo	In vivo, mGluR2 antagonist 1 (Compound 25) reverses the effect of mGluR2 agonist LY379268 in amphetamine-induced hyperlocomotion and shows good efficacy in the mouse delayed non-match to position assay at 10 mg/kg.
References	[1]. Youheng Shu,et al. Discovery of 4-arylquinoline-2-carboxamides, Highly Potent and Selective Class of mGluR2 Negative Allosteric Modulators: From HTS to Activity in Animal Models. Bioorg Med Chem Lett. 2020 May 1;30(9):127066.

Molecular Formula	C₂₁H₁₆FN₃O₃
Molecular Weight	377.37