mGluR2 antagonist 1
Modify Date: 2025-08-27 11:08:24
mGluR2 antagonist 1 structure
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Common Name | mGluR2 antagonist 1 | ||
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| CAS Number | 1432728-49-8 | Molecular Weight | 377.37 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H16FN3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of mGluR2 antagonist 1mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability[1]. |
| Name | mGluR2 antagonist 1 |
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| Description | mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability[1]. |
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| Related Catalog | |
| Target |
mGluR2:9 nM (IC50) |
| In Vivo | In vivo, mGluR2 antagonist 1 (Compound 25) reverses the effect of mGluR2 agonist LY379268 in amphetamine-induced hyperlocomotion and shows good efficacy in the mouse delayed non-match to position assay at 10 mg/kg. |
| References |
| Molecular Formula | C21H16FN3O3 |
|---|---|
| Molecular Weight | 377.37 |
| InChIKey | XSTBUOHORFUCIB-UHFFFAOYSA-N |
| SMILES | NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CN3C(=O)CCC3=O)cc2n1 |