667430-81-1

667430-81-1 structure

Name: PG 931 TFA
Chemical Name: PG-931
CAS Number: 667430-81-1
Molecular Formula: C₅₉H₈₅N₁₅O₁₁
Molecular Weight: 1180.40
Catalog: Research Areas Inflammation/Immunology
Create Date: 2020-08-09 13:03:36
Modify Date: 2024-01-06 18:31:47
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo[2].

Name	PG-931

Description	PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo[2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor
Target	IC50: 0.58 nM (melanocortin 4 receptor) IC50: 2.4 nM (melanocortin 5 receptor) IC50: 55 nM (melanocortin 3 receptor)[1]
In Vivo	PG-931 (intravenous injection; 13-108 nmol/kg; single dose) produces a dose-dependent restoration of cardiovascular and respiratory functions, and improved survival in Wistar rats with haemorrhagic shock[2]. Animal Model: Wistar rats[2] Dosage: 13-108 nmol/kg Administration: Intravenous injection; single dose Result: Exhibitd an anti-shock effect occurred at nanomolar doses.
References	[1]. D Giuliani, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol [2]. P Grieco, et al. Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. J Pept Res