2305815-72-7
2305815-72-7 structure
- Name: R8-T198wt
- Chemical Name: R8-T198wt
- CAS Number: 2305815-72-7
- Molecular Formula: C111H211N59O26S
- Molecular Weight: 2820.33
- Catalog: Signaling Pathways JAK/STAT Signaling Pim
- Create Date: 2020-08-08 18:18:16
- Modify Date: 2025-08-27 07:19:06
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R8-T198wt is a cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. R8-T198wt inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. R8-T198wt also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. R8-T198wt displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.
| Name | R8-T198wt |
|---|
| Description | R8-T198wt is a cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. R8-T198wt inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. R8-T198wt also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. R8-T198wt displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM. |
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| Related Catalog |
| Molecular Formula | C111H211N59O26S |
|---|---|
| Molecular Weight | 2820.33 |