R8-T198wt
Modify Date: 2025-08-27 07:19:06
R8-T198wt structure
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Common Name | R8-T198wt | ||
|---|---|---|---|---|
| CAS Number | 2305815-72-7 | Molecular Weight | 2820.33 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C111H211N59O26S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of R8-T198wtR8-T198wt is a cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. R8-T198wt inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. R8-T198wt also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. R8-T198wt displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM. |
| Name | R8-T198wt |
|---|
| Description | R8-T198wt is a cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. R8-T198wt inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. R8-T198wt also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. R8-T198wt displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM. |
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| Related Catalog |
| Molecular Formula | C111H211N59O26S |
|---|---|
| Molecular Weight | 2820.33 |
| InChIKey | AIRNEKGCZRAELC-NBQUZRIMSA-N |
| SMILES | CC(C)CC(NC(=O)CNC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CS)NC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)CN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(N)=O)C(=O)NC(C(=O)O)C(C)O |