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1328934-40-2

1328934-40-2 structure
1328934-40-2 structure
  • Name: LEE011-D6
  • Chemical Name: Ribociclib D6
  • CAS Number: 1328934-40-2
  • Molecular Formula: C23H24D6N8O
  • Molecular Weight: 440.57
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
  • Create Date: 2020-08-10 15:07:11
  • Modify Date: 2024-01-12 19:11:46
  • Ribociclib D6 (LEE011 D6) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].

Name Ribociclib D6
Description Ribociclib D6 (LEE011 D6) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].
Related Catalog
References

[1]. VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10.

Molecular Formula C23H24D6N8O
Molecular Weight 440.57