Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TL 13-110
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: TL13-110
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

2229037-09-4

2229037-09-4 structure

2229037-09-4 structure

Name: TL 13-110
Chemical Name: TL13-110
CAS Number: 2229037-09-4
Molecular Formula: C₄₉H₆₂ClN₉O₉S
Molecular Weight: 988.59
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ALK
Create Date: 2020-08-09 16:29:45
Modify Date: 2024-01-14 00:33:14
TL13-110 is a negative control for TL13-112 (HY-123919) and a potent ALK inhibitor with an IC50 of 0.34 nM. TL13-110 does not degrade ALK in cells[1].

Name	TL13-110

Description	TL13-110 is a negative control for TL13-112 (HY-123919) and a potent ALK inhibitor with an IC50 of 0.34 nM. TL13-110 does not degrade ALK in cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
Target	IC50: 0.34 nM (ALK); 81 μM (Cereblon)[1]
In Vitro	TL13-110 also prompts the degradation of additional kinases including Aurora A, FER, PTK2 and RPS6KA1 with IC50 values of 9080 nM, 23.1 nM, 21.2 nM, and 480 nM, respectively.
References	[1]. Chelsea E Powell, et al. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK). J Med Chem. 2018 May 10;61(9):4249-4255.

Molecular Formula	C₄₉H₆₂ClN₉O₉S
Molecular Weight	988.59