TL 13-110

Modify Date: 2025-08-26 19:02:04

TL 13-110 Structure
TL 13-110 structure
Common Name TL 13-110
CAS Number 2229037-09-4 Molecular Weight 988.59
Density N/A Boiling Point N/A
Molecular Formula C49H62ClN9O9S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TL 13-110


TL13-110 is a negative control for TL13-112 (HY-123919) and a potent ALK inhibitor with an IC50 of 0.34 nM. TL13-110 does not degrade ALK in cells[1].

 Names

Name TL13-110

 TL 13-110 Biological Activity

Description TL13-110 is a negative control for TL13-112 (HY-123919) and a potent ALK inhibitor with an IC50 of 0.34 nM. TL13-110 does not degrade ALK in cells[1].
Related Catalog
Target

IC50: 0.34 nM (ALK); 81 μM (Cereblon)[1]

In Vitro TL13-110 also prompts the degradation of additional kinases including Aurora A, FER, PTK2 and RPS6KA1 with IC50 values of 9080 nM, 23.1 nM, 21.2 nM, and 480 nM, respectively.
References

[1]. Chelsea E Powell, et al. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK). J Med Chem. 2018 May 10;61(9):4249-4255.

 Chemical & Physical Properties

Molecular Formula C49H62ClN9O9S
Molecular Weight 988.59
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