Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TL 13-22
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: TL13-22
Price: $550.0/5mg $800.0/10mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

2229036-65-9

2229036-65-9 structure

2229036-65-9 structure

Name: TL 13-22
Chemical Name: TL13-22
CAS Number: 2229036-65-9
Molecular Formula: C₄₅H₅₅ClN₁₀O₉S
Molecular Weight: 947.50
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ALK
Create Date: 2020-08-10 19:11:47
Modify Date: 2024-04-09 05:55:08
TL13-22 is a negative control for TL13-12 (HY-122582) and a potent ALK inhibitor with an IC50 of 0.54 nM. TL13-22 does not degrade ALK in cells[1].

Name	TL13-22

Description	TL13-22 is a negative control for TL13-12 (HY-122582) and a potent ALK inhibitor with an IC50 of 0.54 nM. TL13-22 does not degrade ALK in cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
Target	IC50: 0.54 nM (ALK)[1]
In Vitro	TL13-22 prompts the degradation of additional kinases including Aurora A, FER, PTK2, and RPS6KA1 with IC50 values of 11.3 nM, 5.74 nM, 18.4 nM, and 65.9 nM, respectively[1].
References	[1]. Chelsea E Powell, et al. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK). J Med Chem. 2018 May 10;61(9):4249-4255.

Molecular Formula	C₄₅H₅₅ClN₁₀O₉S
Molecular Weight	947.50