1962928-23-9

1962928-23-9 structure

Name: XAC
Chemical Name: Xanthine amine congener dihydrochloride
CAS Number: 1962928-23-9
Molecular Formula: C₂₁H₃₀Cl₂N₆O₄
Molecular Weight: 501.41
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2020-08-07 23:07:22
Modify Date: 2024-01-10 23:06:37
Xanthine amine congener dihydrochloride (XAC dihydrochloride) is a potent Adenosine A1 receptor and A2 receptor antagonist with IC50 values of 1.8 and 114 nM, respectively. Xanthine amine congener acts as a convulsant agent in mice model[1].

Name	Xanthine amine congener dihydrochloride

Description	Xanthine amine congener dihydrochloride (XAC dihydrochloride) is a potent Adenosine A1 receptor and A2 receptor antagonist with IC50 values of 1.8 and 114 nM, respectively. Xanthine amine congener acts as a convulsant agent in mice model[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	IC50: 1.8 nM (Adenosine A1 receptor) IC50: 114 nM (Adenosine A2 receptor)[1]
In Vivo	Xanthine amine congener dihydrochloride is more potent as a convulsant than either caffeine or theophyllin in infusion studies at the dosage 39.8 mg/kg. XAC has no effects by administering the drug via an i.p. injection, the seizure threshold >1000 mg/kg[1]. Animal Model: Mice[1] Dosage: 39.8 mg/kg Administration: Infusion injection; single dose Result: Acted as a convulsant agent than either caffeine or theophyllin.
References	[1]. P F Morgan, et al.Potent Convulsant Actions of the Adenosine Receptor Antagonist, Xanthine Amine Congener (XAC). Life Sci. 1989;45(8):719-28

Molecular Formula	C₂₁H₃₀Cl₂N₆O₄
Molecular Weight	501.41