| Description |
Xanthine amine congener dihydrochloride (XAC dihydrochloride) is a potent Adenosine A1 receptor and A2 receptor antagonist with IC50 values of 1.8 and 114 nM, respectively. Xanthine amine congener acts as a convulsant agent in mice model[1].
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| Related Catalog |
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| Target |
IC50: 1.8 nM (Adenosine A1 receptor) IC50: 114 nM (Adenosine A2 receptor)[1]
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| In Vivo |
Xanthine amine congener dihydrochloride is more potent as a convulsant than either caffeine or theophyllin in infusion studies at the dosage 39.8 mg/kg. XAC has no effects by administering the drug via an i.p. injection, the seizure threshold >1000 mg/kg[1]. Animal Model: Mice[1] Dosage: 39.8 mg/kg Administration: Infusion injection; single dose Result: Acted as a convulsant agent than either caffeine or theophyllin.
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| References |
[1]. P F Morgan, et al.Potent Convulsant Actions of the Adenosine Receptor Antagonist, Xanthine Amine Congener (XAC). Life Sci. 1989;45(8):719-28
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