1926163-57-6

1926163-57-6 structure

Name: Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt
Chemical Name: Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt
CAS Number: 1926163-57-6
Molecular Formula: C₃₁H₄₉FN₁₀O₆
Molecular Weight: 676.78
Catalog: Signaling Pathways NF-κB MALT1
Create Date: 2021-01-11 01:01:25
Modify Date: 2023-01-15 14:20:56
Val-Arg-Pro-DL-Arg-Fluoromethylketone is a potent MALT1 inhibitor. Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits cell proliferation and migration. Val-Arg-Pro-DL-Arg-Fluoromethylketone shows anticancer activity[1].

Name	Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt
Synonyms	L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-arginyl-N-[1-[3-[(aminoiminomethyl)amino]propyl]-4-fluoro-2,3-dioxobutyl]- N-[(Benzyloxy)carbonyl]-L-valyl-L-arginyl-N-(7-carbamimidamido-1-fluoro-2,3-dioxo-4-heptanyl)-L-prolinamide

Description	Val-Arg-Pro-DL-Arg-Fluoromethylketone is a potent MALT1 inhibitor. Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits cell proliferation and migration. Val-Arg-Pro-DL-Arg-Fluoromethylketone shows anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> NF-κB >> MALT1
Target	MALT1[1]
In Vitro	Val-Arg-Pro-DL-Arg-Fluoromethylketone (75 mol/L; 6, 12, 24, 36, and 48 h) 抑制 OCI-LY10 细胞的增殖和迁移[1]。 Cell Proliferation Assay[1] Cell Line: OCI-LY10 cells Concentration: 75 mol/L Incubation Time: 6, 12, 24, 36, and 48 h Result: Inhibited the proliferation and migration of OCI-LY10 cells.
In Vivo	Val-Arg-Pro-DL-Arg-Fluoromethylketone (37.5 M0.2 mL；每隔一天，持续 12 天) 抑制小鼠肿瘤的生长[1]。 Animal Model: 4-6 weeks, 16-20 g, Female BALB/c nude mice (OCI-LY10 cells)[1] Dosage: 37.5 M0.2 mL Administration: Every other day for 12 days Result: Inhibited the growth of the xenografts and decreased the expression of P65.
References	[1]. Feng J, et al. Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1. Int J Clin Exp Pathol. 2019 Jun 1;12(6):1947-1955.