DC Chemicals Limited
China
Product Name: 5-Carboxamidotryptamine maleate
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

74885-72-6

74885-72-6 structure

74885-72-6 structure

Name: 5-Carboxamidotryptamine maleate
Chemical Name: 5-Carboxamidotryptamine maleate
CAS Number: 74885-72-6
Molecular Formula: C₁₅H₁₇N₃O₅
Molecular Weight: 319.31
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2021-01-16 00:51:57
Modify Date: 2024-01-03 18:34:57
5-Carboxamidotryptamine maleate (5-CT maleate) is a potent 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5 and 5-HT7 receptors agonist[1][2][3].

Name	5-Carboxamidotryptamine maleate
Synonyms	MFCD00069224

Description	5-Carboxamidotryptamine maleate (5-CT maleate) is a potent 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5 and 5-HT7 receptors agonist[1][2][3].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT1A Receptor 5-HT1B Receptor 5-HT1D Receptor 5-HT5 Receptor 5-HT7 Receptor
In Vitro	[3H]-5-Carboxamidotryptamine (5-CT) binding to 5-HT1D sites in bovine substantia nigra is rapid, reversible and saturable, displaying high affinity (Kd = 0.38 nM) and low non-specific binding[2]. In bovine substantia nigra, [3H]-5-Carboxamidotryptamine (5-CT) labelled an equivalent number of binding sites to [3H]-5-Carboxamidotryptamine (403 and 362 fmol/mg protein, respectively) and binding is sensitive to guanine nucleotides[2].
In Vivo	Topical 5-Carboxamidotryptamine (0.01-1000 μM) to the exposed dura mater encephala produced decreases in diastolic blood pressure, variable changes in meningeal blood flow and increases in conductance (i.e. dilatation) in the middle meningeal artery of anesthetized Wistar rats (serotonin depletion and treated with 20 mg/kg corticosterone)[1].
References	[1]. E Martínez-García, et al. 5-HT7 receptor-mediated meningeal dilatation induced by 5-carboxamidotryptamine in rats is not altered by 5-HT depletion and chronic corticosterone treatment. Proc West Pharmacol Soc. 2011;54:57-61. [2]. H P Nowak, et al. [3H]-5-carboxamidotryptamine labels 5-HT1D binding sites in bovine substantia nigra. Br J Pharmacol. 1993 Aug;109(4):1206-11. [3]. J Yamada, et al. Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats. Eur J Pharmacol. 1998 Oct 16;359(1):81-6.

Molecular Formula	C₁₅H₁₇N₃O₅
Molecular Weight	319.31
Storage condition	-20°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
RIDADR	NONH for all modes of transport