2120398-39-0
2120398-39-0 structure
- Name: Chk1-IN-5
- Chemical Name: Chk1-IN-5
- CAS Number: 2120398-39-0
- Molecular Formula: C18H18FN7O2
- Molecular Weight: 383.38
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Checkpoint Kinase (Chk)
- Create Date: 2020-10-17 21:19:55
- Modify Date: 2024-01-10 13:18:20
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Chk1-IN-5 is a potent checkpoint kinase 1 (Chk1) inhibitor. Chk1-IN-5 inhibits Chk1 phosphorylation and inhibits tumor growth in colon cancer xenograft model[1].
| Name | Chk1-IN-5 |
|---|
| Description | Chk1-IN-5 is a potent checkpoint kinase 1 (Chk1) inhibitor. Chk1-IN-5 inhibits Chk1 phosphorylation and inhibits tumor growth in colon cancer xenograft model[1]. |
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| Related Catalog | |
| Target |
Chk1 |
| In Vitro | Chk1-IN-5 (compound 3; 0.4, 1.2, 3.7, 11.1, 33.3, 100 nM) inhibits Chk1 phosphorylation in the HT-29 colon cells[1]. |
| In Vivo | Chk1-IN-5 (compound 3; 40 mg/kg; IV; twice a week for 21 days) inhibits tumor growth in Baib/c nude mice with HT-29 colon cancer cells[1]. Chk1-IN-5 (10 mg/kg; via tail vein intravenous injection) displays a longer half-life (T1/2=3.8 hours) and higher exposure (CL=2.3 L/hr•kg; Vss=6.4 L/kg; AUC=4531 ng/ml•h)[1]. Animal Model: Baib/c nude mice with HT-29 colon cancer cells[1] Dosage: 40 mg/kg Administration: IV; twice a week for 21 days Result: Inhibited tumor growth. Animal Model: Male SD rats (280-350 g)[1] Dosage: 10 mg/kg Administration: Via tail vein intravenous injection Result: Displayed a longer half-life (T1/2=3.8 hours) and higher exposure (CL=2.3 L/hr•kg; Vss=6.4 L/kg; AUC=4531 ng/ml•h). |
| References |
| Molecular Formula | C18H18FN7O2 |
|---|---|
| Molecular Weight | 383.38 |
| Hazard Codes | Xi |
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