2285446-67-3

2285446-67-3 structure

Name: (E/Z)-E64FC26
Chemical Name: (E/Z)-E64FC26
CAS Number: 2285446-67-3
Molecular Formula: C₁₉H₂₃F₃O₂
Molecular Weight: 340.38
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2021-01-19 22:48:59
Modify Date: 2024-01-05 20:00:26
(E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity[1][2].

Name	(E/Z)-E64FC26

Description	(E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Nathan G. Dolloff, et al. Indene derivatives and uses thereof. US20190062298A1. [2]. Robinson RM, et al. Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma. Leukemia. 2019 Apr;33(4):1011-1022.

Molecular Formula	C₁₉H₂₃F₃O₂
Molecular Weight	340.38