84709-25-1
84709-25-1 structure
- Name: (-)-Zuonin A
- Chemical Name: (-)-Zuonin A
- CAS Number: 84709-25-1
- Molecular Formula: C20H20O5
- Molecular Weight: 340.37
- Catalog: Signaling Pathways MAPK/ERK Pathway JNK
- Create Date: 2020-10-19 18:03:35
- Modify Date: 2024-01-04 19:52:03
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(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively[1].
| Name | (-)-Zuonin A |
|---|
| Description | (-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively[1]. |
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| Related Catalog | |
| Target |
JNK1:1.7 μM (IC50) JNK2:2.9 μM (IC50) JNK3:1.74 μM (IC50) |
| In Vitro | (−)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs[1]. (−)-zuonin A inhibits JNK activation by MKK4 and MKK7 and it inhibits substrate phosphorylation[1]. |
| References |
| Molecular Formula | C20H20O5 |
|---|---|
| Molecular Weight | 340.37 |
| Hazard Codes | Xi |
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