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  • DC Chemicals Limited
  • China
  • Product Name: PM226
  • Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

1949726-13-9

1949726-13-9 structure
1949726-13-9 structure
  • Name: PM 226
  • Chemical Name: PM226
  • CAS Number: 1949726-13-9
  • Molecular Formula: C22H31NO3
  • Molecular Weight: 357.49
  • Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
  • Create Date: 2020-11-21 18:45:41
  • Modify Date: 2024-01-12 11:01:39
  • PM226 is a selective cannabinoid CB2R agonist (Ki (CB2)=13 nM; EC50 (CB2)=39 nM; Ki (CB1R) >40 μM;) with neuroprotective properties in vitro and vivo[1].

Name PM226
Description PM226 is a selective cannabinoid CB2R agonist (Ki (CB2)=13 nM; EC50 (CB2)=39 nM; Ki (CB1R) >40 μM;) with neuroprotective properties in vitro and vivo[1].
Related Catalog
Target

CB2:13 nM (Ki)

CB2:39 nM (EC50)

In Vitro PM226 binds selectively to CB2 receptor with an affinity in the nanomolar range (Ki=12.8±2.4 nM). PM226 has negligible affinity for the CB1 receptor (Ki >40000 nM) and no activity at the GPR55. PM226 was also evaluated in GTPγS binding assays specific to the CB2 receptor showing agonist activity (EC50=38.67±6.70 nM)[2].
In Vivo PM226 (0.1, 1 and 10 mg/kg; administered i.p.) administration decreases the volume of the striatal lesion caused by Malonate[2]. Animal Model: Malonate-lesioned adult (12 week old; 350-400 g) male Wistar rats[2] Dosage: 0.1, 1 and 10 mg/kg Administration: Administered i.p. Result: Reduced the volume of edema observed in Malonate-lesioned rats at the dose of 1 mg/kg.
References

[1]. Gemma Navarro, et al. Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders. Front Neurosci. 2016 Sep 13;10:406.

[2]. M Gómez-Cañas, et al. Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile. Pharmacol Res. 2016 Aug;110:205-215.

Molecular Formula C22H31NO3
Molecular Weight 357.49