2454492-41-0
2454492-41-0 structure
- Name: TC-2559 difumarate
- Chemical Name: TC-2559 difumarate
- CAS Number: 2454492-41-0
- Molecular Formula: C20H26N2O9
- Molecular Weight: 438.43
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
- Create Date: 2020-10-19 18:00:50
- Modify Date: 2025-08-26 19:02:19
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TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC50s in the range of 10-30 µM. Antinociceptive effect[1][2].
| Name | TC-2559 difumarate |
|---|
| Description | TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC50s in the range of 10-30 µM. Antinociceptive effect[1][2]. |
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| Related Catalog | |
| In Vivo | TC-2559 difumarate (1-10 mg/kg; i.p.) dose dependently reduces acute formalin-induced biphasic nociceptive responses in mice[2]. TC-2559 difumarate (0.3-3 mg/kg; i.p.) dose dependently inhibits CCI-induced neuropathic pain in rats[2]. Animal Model: Adult male mice (body weight 15-30 g) (formalin test)[2] Dosage: 1, 3, 10 mg/kg Administration: I.p. Result: Dose dependently reduced both early and late phases of formalin induced nociceptive behavioral responses. Animal Model: Adult male SD rats (body weight 200-220 g) (chronic constriction injury (CCI))[2] Dosage: 0.3, 1, 3 mg/kg Administration: I.p. Result: Significantly reversed CCI induced the paw withdrawal threshold decreases. |
| References |
| Molecular Formula | C20H26N2O9 |
|---|---|
| Molecular Weight | 438.43 |