2415003-97-1

2415003-97-1 structure

Name: yGsy2p-IN-1
Chemical Name: yGsy2p-IN-1
CAS Number: 2415003-97-1
Molecular Formula: C₁₆H₁₁F₃N₂O₄
Molecular Weight: 352.26
Catalog: Research Areas Metabolic Disease
Create Date: 2021-01-12 18:59:58
Modify Date: 2025-08-26 19:30:42
yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC50 of 2.75 µM and a Ki of 1.31 µM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs)[1].

Name	yGsy2p-IN-1

Description	yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC50 of 2.75 µM and a Ki of 1.31 µM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs)[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	IC50: 2.75 µM (hGYS1)[1] Ki: 1.31 µM (wild-type hGYS1)[1]
In Vitro	yGsy2p-IN-1 (compound 23; 0.1, 1, 10, 100, 1000 µM) has IC50s of 7.89 μM and 33.6 μM for yGsy2p-WT and yGsy2p-Y513L[1]. yGsy2p-IN-1 (100 μM) exhibits almost complete inhibition of synthase activity in both HEK293-PTG and Rat-1 cell lysates[1].
References	[1]. Buyun Tang, et al. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J Med Chem. 2020 Apr 9;63(7):3538-3551.

Molecular Formula	C₁₆H₁₁F₃N₂O₄
Molecular Weight	352.26