1207610-07-8

1207610-07-8 structure

Name: LDV FITC
Chemical Name: LDV FITC
CAS Number: 1207610-07-8
Molecular Formula: C₆₉H₈₁N₁₁O₁₇S
Molecular Weight: 1368.510
Catalog: Signaling Pathways Cytoskeleton Integrin
Create Date: 2020-12-28 18:33:56
Modify Date: 2024-02-05 22:54:59
LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with high affinity (Kd: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). LDV-FITC can be used to detect α4β1 integrin affinity[1][2].

Name	LDV FITC
Synonyms	N-[(4-{[(2-Methylphenyl)carbamoyl]amino}phenyl)acetyl]-L-leucyl-L-α-aspartyl-L-valyl-L-prolyl-L-alanyl-L-alanyl-N6-{[4-carboxy-3-(6-hydroxy-3-oxo-3H-xanthen-9-yl)phenyl]carbamothioyl}-L-lysine L-Lysine, N-[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]-L-leucyl-L-α-aspartyl-L-valyl-L-prolyl-L-alanyl-L-alanyl-N6-[[[4-carboxy-3-(6-hydroxy-3-oxo-3H-xanthen-9-yl)phenyl]amino] thioxomethyl]-

Description	LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with high affinity (Kd: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). LDV-FITC can be used to detect α4β1 integrin affinity[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> Integrin
Target	α4β1 integrin[1]
References	[1]. Hyduk SJ, et al. Phospholipase C, calcium, and calmodulin are critical for alpha4beta1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants. Blood. 2007 Jan 1;109(1):176-84. [2]. Chigaev A, et al. Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation. J Biol Chem. 2001 Dec 28;276(52):48670-8.