LDV FITC

Modify Date: 2024-02-05 22:54:59

LDV FITC Structure
LDV FITC structure
Common Name LDV FITC
CAS Number 1207610-07-8 Molecular Weight 1368.510
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C69H81N11O17S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LDV FITC


LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with high affinity (Kd: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). LDV-FITC can be used to detect α4β1 integrin affinity[1][2].

 Names

Name LDV FITC
Synonym More Synonyms

 LDV FITC Biological Activity

Description LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with high affinity (Kd: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). LDV-FITC can be used to detect α4β1 integrin affinity[1][2].
Related Catalog
Target

α4β1 integrin[1]

References

[1]. Hyduk SJ, et al. Phospholipase C, calcium, and calmodulin are critical for alpha4beta1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants. Blood. 2007 Jan 1;109(1):176-84.  

[2]. Chigaev A, et al. Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation. J Biol Chem. 2001 Dec 28;276(52):48670-8.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C69H81N11O17S
Molecular Weight 1368.510
Exact Mass 1367.553223
LogP 6.55
Index of Refraction 1.676

 Synonyms

N-[(4-{[(2-Methylphenyl)carbamoyl]amino}phenyl)acetyl]-L-leucyl-L-α-aspartyl-L-valyl-L-prolyl-L-alanyl-L-alanyl-N6-{[4-carboxy-3-(6-hydroxy-3-oxo-3H-xanthen-9-yl)phenyl]carbamothioyl}-L-lysine
L-Lysine, N-[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]-L-leucyl-L-α-aspartyl-L-valyl-L-prolyl-L-alanyl-L-alanyl-N6-[[[4-carboxy-3-(6-hydroxy-3-oxo-3H-xanthen-9-yl)phenyl]amino] thioxomethyl]-
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