132196-54-4

132196-54-4 structure

Name: Chrodrimanin B
Chemical Name: (-)-Chrodrimanin B
CAS Number: 132196-54-4
Molecular Formula: C₂₇H₃₂O₈
Molecular Weight: 484.538
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2021-01-10 16:13:35
Modify Date: 2024-01-13 23:21:35
Chrodrimanin B, a metabolite of a fungal, is a potent, non-open-channel-blocking antagonist on B. mori GABAR RDL with an IC50 of 1.13 nM. Chrodrimanin B attenuates the peak current amplitude of the GABA response of RDL with an IC50 of 1.66 nM. Chrodrimanin B, a meroterpenoid, shows insecticidal activity[1].

Name	(-)-Chrodrimanin B
Synonyms	(-)-Chrodrimanin B chrodrimanin B (1R,2R,7aR,8S,9aR,13aS,13bS)-5,8-Dihydroxy-2,7a,10,10,13a-pentamethyl-4,11-dioxo-1,7a,8,9,9a,10,11,13a,13b,14-decahydro-2H,4H-benzo[a]pyrano[3,4-j]xanthen-1-yl acetate 2H,4H-Benzo[a]pyrano[3,4-j]xanthene-4,11(7aH)-dione, 1-(acetyloxy)-1,8,9,9a,10,13a,13b,14-octahydro-5,8-dihydroxy-2,7a,10,10,13a-pentamethyl-, (1R,2R,7aR,8S,9aR,13aS,13bS)-

Description	Chrodrimanin B, a metabolite of a fungal, is a potent, non-open-channel-blocking antagonist on B. mori GABAR RDL with an IC50 of 1.13 nM. Chrodrimanin B attenuates the peak current amplitude of the GABA response of RDL with an IC50 of 1.66 nM. Chrodrimanin B, a meroterpenoid, shows insecticidal activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	Chrodrimanin B exhibits much weaker blocking action on human α1β2γ2 GABAR compared to RDL (IC50=1.48 μM)[1]. Chrodrimanin B shows competitive actions at low concentrations and non-competitive actions at higher concentrations on B. mori GABAR RDL[1].
References	[1]. Yan Xu, et al. Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels. PLoS One. 2015 Apr 22;10(4):e0122629.