163727-74-0

163727-74-0 structure

Name: WIN 64338 hydrochloride
Chemical Name: (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride
CAS Number: 163727-74-0
Molecular Formula: C₄₅H₆₉Cl₂N₄OP
Molecular Weight: 783.935
Catalog: Signaling Pathways GPCR/G Protein Bradykinin Receptor
Create Date: 2021-01-09 18:03:34
Modify Date: 2025-08-27 16:17:03
WIN 64338 hydrochloride is a potent, selective, nonpeptide competitive antagonist of bradykinin B2 receptor. WIN 64338 hydrochloride inhibits [3H]-Bradykinin binding to the bradykinin B2 receptor on human IMR-90 cells with a Ki of 64 nM. WIN 64338 hydrochloride also can inhibits [3H]Quinuclidinyl benzilate binding to the rat brain muscarinic receptor (Ki=350 nM)[1][2].

Name	(S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride
Synonyms	(S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride Phosphonium, tributyl[[4-[[(2S)-2-[[(E)-(cyclohexylamino)(cyclohexylimino)methyl]amino]-3-(2-naphthalenyl)-1-oxopropyl]amino]phenyl]methyl]-, chloride, hydrochloride (1:1:1) N2-(N,N'-Dicyclohexylcarbamimidoyl)-3-(2-naphthyl)-N-{4-[(tributylphosphonio)methyl]phenyl}-L-alaninamide chloride hydrochloride (1:1:1) phosphonium, tributyl[[4-[[(2S)-2-[[(E)-(cyclohexylamino)(cyclohexyliminio)methyl]amino]-3-(2-naphthalenyl)-1-oxopropyl]amino]phenyl]methyl]-, chloride (1:2)

Description	WIN 64338 hydrochloride is a potent, selective, nonpeptide competitive antagonist of bradykinin B2 receptor. WIN 64338 hydrochloride inhibits [3H]-Bradykinin binding to the bradykinin B2 receptor on human IMR-90 cells with a Ki of 64 nM. WIN 64338 hydrochloride also can inhibits [3H]Quinuclidinyl benzilate binding to the rat brain muscarinic receptor (Ki=350 nM)[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor
Target	Ki: 64 nM (bradykinin B2 receptor)[1], 350 nM (muscarinic receptor)[2]
In Vitro	WIN 64338 hydrochloride competitively inhibits Bradykinin-stimulated 45Ca2+ efflux from IMR-90 cells (pA2=7.1)[1]. WIN 64338 hydrochloride inhibits Bradykinin-mediated guinea pig ileum contractility (pA2=8.2)[1]. WIN 64338 hydrochloride inhibits Bradykinin-induced contraction of guinea-pig trachea, with a KB of 64.3 nM[2].
In Vivo	WIN 64338 (5 mg/kg; i.p.) hydrochloride decreases the physiological anxiety measure, stress-induced hyperthermia (SIH) of mice[3].
References	[1]. Sawutz DG, et, al. The nonpeptide WIN 64338 is a bradykinin B2 receptor antagonist. Proc Natl Acad Sci U S A. 1994 May 24;91(11):4693-7. [2]. Scherrer D, et, al. Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea. Br J Pharmacol. 1995 Aug;115(7):1127-8. [3]. Rouhiaine A, et, al. The bradykinin system in stress and anxiety in humans and mice. Sci Rep. 2019 Dec 19;9(1):19437.

Molecular Formula	C₄₅H₆₉Cl₂N₄OP
Molecular Weight	783.935
Exact Mass	782.458618

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

163727-74-0	5636-91-9
73360-54-0	550-83-4
568-69-4	63867-26-5
97174-79-3	15826-61-6
14252-80-3	102338-93-2
2770630-92-5	2770602-29-2
2228256-50-4	2137463-06-8
2228550-54-5	2228944-90-7
2005323-99-7	2137678-92-1
2138356-44-0	2228781-43-7