168705-70-2

168705-70-2 structure

Name: SY-640
Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-N-methylacetamide
CAS Number: 168705-70-2
Molecular Formula: C₁₁H₁₃NO₃
Molecular Weight: 207.226
Catalog: Research Areas Metabolic Disease
Create Date: 2021-09-16 06:58:14
Modify Date: 2024-01-13 22:42:59
SY-640 is an Acetamide derivative and has potent hepatoprotective effect. SY-640 reduces Propionibacterium acnes and Lipopolysaccharide-induced liver injury in mice[1][2].

Name	N-(1,3-Benzodioxol-5-ylmethyl)-N-methylacetamide
Synonyms	Acetamide, N-(1,3-benzodioxol-5-ylmethyl)-N-methyl- N-(1,3-Benzodioxol-5-ylmethyl)-N-methylacetamide MFCD20143110

Description	SY-640 is an Acetamide derivative and has potent hepatoprotective effect. SY-640 reduces Propionibacterium acnes and Lipopolysaccharide-induced liver injury in mice[1][2].
Related Catalog	Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	SY-640 inhibits the number of liver-infiltrating cells and attenuates the increased expression of leukocyte function-associated antigen-1 on these cells[1].
In Vivo	SY-640 (Oral; 150 mg/kg; once daily for 7 days) significantly inhibits Propionibacterium acnes and Lipopolysaccharide-induced liver injury, but a single administration is without effect[1]. SY-640 (p.o.; 150 mg/kg; once daily for three days) significantly increases the liver microsomal cytochrome P-450 content and aminopyrine demethylase activity in mice. The hepatic microsomal aminopyrine demethylase activity is obviously inhibited two hours after oral administration of SY-640[2].
References	[1]. Y Tanaka, et al. Hepatoprotective effect of SY-640, a novel acetamide derivative, on Propionibacterium acnes and lipopolysaccharide-induced liver injury in mice. Arch Int Pharmacodyn Ther. Mar-Apr 1995;329(2):319-30. [2]. P F Li, et al. [Inhibitory effect of 2-(N-acetyl-methyl amino)-3',4'-methylenedioxyacetyl-aminophene(SY-640) on covalent binding of carcinogenic benzo(a)pyrene with mouse hepatocyte nuclear DNA]. Yao Xue Xue Bao. 1997 Sep;32(9):663-8.