1906920-28-2

1906920-28-2 structure

Name: BAY-598 R-isomer
Chemical Name: (R)-BAY-598
CAS Number: 1906920-28-2
Molecular Formula: C₂₂H₂₀Cl₂F₂N₆O₃
Molecular Weight: 525.335
Create Date: 2021-01-08 07:31:20
Modify Date: 2025-08-25 18:12:53
BAY-598 R-isomer is the R-isomer of BAY589. BAY-598 R-isomer may be used as a reference compound. BAY-598 is a potent, peptide-competitive chemical probe for SMYD2. BAY-598 has a unique chemotype relative to the current SMYD2 chemical probe LLY-507. BAY-598 inhibits in vitro methylation of p53K370 with IC50 = 27 nM and has more than 100-fold selectivity over other histone methyltransferases and other non-epigenetic targets. BAY-598 inhibits the methylation of p53K370 in cells with IC50 < 1 μM. (Further to this, BAY-598 has properties that are compatible with in vivo experiments.) A control compound, BAY-369, has also been developed. BAY-369 inhibits the in vitro methylation of p53K370 with IC50 > 70 micromolar.

Name	(R)-BAY-598
Synonyms	Acetamide, N-[(4R)-1-[(Z)-(cyanoimino)[[3-(difluoromethoxy)phenyl]amino]methyl]-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl]-N-ethyl-2-hydroxy- N-[(4R)-1-{N'-Cyano-N-[3-(difluoromethoxy)phenyl]carbamimidoyl}-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl]-N-ethyl-2-hydroxyacetamide (R)-BAY-598