2086689-05-4

2086689-05-4 structure

Name: 2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane
Chemical Name: 1-Azido-14-[(2-carboxyethoxy)methyl]-12-oxo-3,6,9,16-tetraoxa-13-azanonadecan-19-oic acid
CAS Number: 2086689-05-4
Molecular Formula: C₁₈H₃₂N₄O₁₀
Molecular Weight: 464.467
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2021-01-10 01:02:51
Modify Date: 2024-01-19 11:51:00
2-Azido-PEG3-amido-13-biscarboxylethoxypropane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1-Azido-14-[(2-carboxyethoxy)methyl]-12-oxo-3,6,9,16-tetraoxa-13-azanonadecan-19-oic acid
Synonyms	3,6,9,16-Tetraoxa-13-azanonadecan-19-oic acid, 1-azido-14-[(2-carboxyethoxy)methyl]-12-oxo- 1-Azido-14-[(2-carboxyethoxy)methyl]-12-oxo-3,6,9,16-tetraoxa-13-azanonadecan-19-oic acid

Description	2-Azido-PEG3-amido-13-biscarboxylethoxypropane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562