2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane

Modify Date: 2024-01-19 11:51:00

2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane Structure
2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane structure
Common Name 2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane
CAS Number 2086689-05-4 Molecular Weight 464.467
Density N/A Boiling Point N/A
Molecular Formula C18H32N4O10 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane


2-Azido-PEG3-amido-13-biscarboxylethoxypropane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1-Azido-14-[(2-carboxyethoxy)methyl]-12-oxo-3,6,9,16-tetraoxa-13-azanonadecan-19-oic acid
Synonym More Synonyms

  Biological Activity

Description 2-Azido-PEG3-amido-13-biscarboxylethoxypropane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C18H32N4O10
Molecular Weight 464.467
Exact Mass 464.211853
LogP -1.20

 Synonyms

3,6,9,16-Tetraoxa-13-azanonadecan-19-oic acid, 1-azido-14-[(2-carboxyethoxy)methyl]-12-oxo-
1-Azido-14-[(2-carboxyethoxy)methyl]-12-oxo-3,6,9,16-tetraoxa-13-azanonadecan-19-oic acid
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