2100306-47-4

2100306-47-4 structure

Name: N-(Amino-PEG1)-N-bis(PEG2-propargyl)
Chemical Name: 6-{2-[2-(2-Propyn-1-yloxy)ethoxy]ethyl}-3,9,12-trioxa-6-azapentadec-14-yn-1-amine
CAS Number: 2100306-47-4
Molecular Formula: C₁₈H₃₂N₂O₅
Molecular Weight: 356.457
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2021-01-07 18:26:28
Modify Date: 2024-01-14 16:34:30
N-(Amino-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	6-{2-[2-(2-Propyn-1-yloxy)ethoxy]ethyl}-3,9,12-trioxa-6-azapentadec-14-yn-1-amine
Synonyms	6-{2-[2-(2-Propyn-1-yloxy)ethoxy]ethyl}-3,9,12-trioxa-6-azapentadec-14-yn-1-amine MFCD30723225 3,9,12-Trioxa-6-azapentadec-14-yn-1-amine, 6-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]-

Description	N-(Amino-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.