401600-86-0
401600-86-0 structure
- Name: STX140
- Chemical Name: STX140
- CAS Number: 401600-86-0
- Molecular Formula: C19H28N2O7S2
- Molecular Weight: 460.565
- Create Date: 2021-01-14 18:53:30
- Modify Date: 2024-08-09 14:29:32
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STX140 is a bis-sulfamate derivative of the endogenous steroid 2-methoxyestradiol, has shown promising anticancer potency both in vitro and in vivo, with excellent bioavailability. STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells. STX140 causes apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells.
| Name | STX140 |
|---|---|
| Synonyms |
STX140
Sulfamic acid, (17β)-2-methoxyestra-1(10),2,4-triene-3,17-diyl ester (9β,13α,14β,17α)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIYL DISULFAMATE (17β)-2-Methoxyestra-1(10),2,4-triene-3,17-diyl disulfamate |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 644.8±65.0 °C at 760 mmHg |
| Molecular Formula | C19H28N2O7S2 |
| Molecular Weight | 460.565 |
| Flash Point | 343.8±34.3 °C |
| Exact Mass | 460.133789 |
| LogP | 3.01 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.629 |