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869298-31-7

869298-31-7 structure
869298-31-7 structure
  • Name: FINO2
  • Chemical Name: FINO2
  • CAS Number: 869298-31-7
  • Molecular Formula: C15H28O3
  • Molecular Weight: 256.38
  • Catalog: Signaling Pathways Apoptosis Ferroptosis
  • Create Date: 2021-01-07 15:32:37
  • Modify Date: 2024-01-11 14:18:34
  • FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation[1].

Name FINO2
Synonyms FINO2
1,2-Dioxaspiro[4.5]decane-3-ethanol, 8-(1,1-dimethylethyl)-3-methyl-
2-[(5s,8s)-3-Methyl-8-(2-methyl-2-propanyl)-1,2-dioxaspiro[4.5]dec-3-yl]ethanol
Description FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation[1].
Related Catalog
In Vitro FINO2 (10 µM; 24 h) induce ferroptosis and shows iron dependence of lipid peroxidation in HT-1080 cells[1].
References

[1]. Gaschler MM, et al. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018 May;14(5):507-515.

Density 1.0±0.1 g/cm3
Boiling Point 323.8±11.0 °C at 760 mmHg
Molecular Formula C15H28O3
Molecular Weight 256.38
Flash Point 149.6±19.3 °C
Exact Mass 256.203857
LogP 3.60
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.491
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