947018-15-7
947018-15-7 structure
- Name: J9
- Chemical Name: Glucocorticoid Resistance Inhibitor
- CAS Number: 947018-15-7
- Molecular Formula: C12H12N4
- Molecular Weight: 212.251
- Catalog: Research Areas Cancer
- Create Date: 2021-01-08 23:39:43
- Modify Date: 2024-04-09 22:29:02
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J9 is a small molecule that reverses Dexamethasone (HY-14648) resistance in T-cell acute lymphoblastic leukemia. J9 is lethal to CUTLL1 cells only in the presence of Dexamethasone. J9 inhibits CUTLL1 cell growth with an EC50 of 28 μM in combination with Dexamethasone[1].
| Name | Glucocorticoid Resistance Inhibitor |
|---|---|
| Synonyms |
2-Pyrimidinamine, 4-cyclopropyl-5-(4-pyridinyl)-
Glucocorticoid Resistance Inhibitor MFCD11051713 4-Cyclopropyl-5-(4-pyridinyl)-2-pyrimidinamine |
| Description | J9 is a small molecule that reverses Dexamethasone (HY-14648) resistance in T-cell acute lymphoblastic leukemia. J9 is lethal to CUTLL1 cells only in the presence of Dexamethasone. J9 inhibits CUTLL1 cell growth with an EC50 of 28 μM in combination with Dexamethasone[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 449.7±55.0 °C at 760 mmHg |
| Molecular Formula | C12H12N4 |
| Molecular Weight | 212.251 |
| Flash Point | 256.3±18.7 °C |
| Exact Mass | 212.106201 |
| LogP | 1.28 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.668 |