1435781-74-0
1435781-74-0 structure
- Name: WKYMVM-NH2 TFA
- Chemical Name: WKYMVM-NH2 TFA
- CAS Number: 1435781-74-0
- Molecular Formula: C43H62F3N9O9S2
- Molecular Weight: 970.13
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2021-01-25 11:03:52
- Modify Date: 2024-01-16 09:52:23
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WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase[1][2][3].
| Name | WKYMVM-NH2 TFA |
|---|
| Description | WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase[1][2][3]. |
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| Related Catalog | |
| In Vitro | WKYMVM-NH2 TFA (10-1000 nM; 24 hours) induces Caco-2 cells proliferation[3]. Cell Proliferation Assay[3] Cell Line: Caco-2 cells (the intestinal epithelial cells) Concentration: 0 nM, 10 nM, 100 nM, 1000 nM Incubation Time: 24 hours Result: Induced cell proliferation. |
| In Vivo | WKYMVM-NH2 TFA (8 mg/kg; six times; for 5 days) ameliorates DSS-induced ulcerative colitis[3]. WKYMVM-NH2 TFA affects cytokine (IL-17, IFN-γ, IL-6, IL-1β and TNF-α) profiles in the DSS colitis model[3]. Animal Model: Six-week-old C57BL/6 mice, DSS model[3] Dosage: 8 mg/kg Administration: Subcutaneously injected, six subcutaneous administrations at 12-h intervals, for 5 days Result: Attenuated the DSS-induced increase in the bleeding score and the stool score. |
| References |
| Molecular Formula | C43H62F3N9O9S2 |
|---|---|
| Molecular Weight | 970.13 |